Publication: Estudio de correlación entre citoquinas proinflamatorias en lágrima y humor acuoso con el edema macular cistoide postcirugía de catarata
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2023-04-17
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Universidad Complutense de Madrid
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Abstract
Las cataratas siguen siendo una de las principales causas de ceguera en todo el mundo. La cirugía de catarata es el tratamiento curativo de elección. El edema macular cistoidepseudoafáquico (EMCP) es la causa más común de la pérdida de visión posoperatoria, que se manifiesta por acumulación de líquido en el área macular a las 4 a 6 semanas después de la cirugía. Se trata de una complicación autolimitada cuya fisiopatología sigue siendo, en parte, desconocida. Actualmente, la prueba multiplex basada en microesferas permite analizar simultáneamente variascitoquinas/quimioquinas, el uso de esta tecnología podría contribuir a mejorar la comprensión delpapel de estas moléculas en la fisiopatología de varias enfermedades. Hasta donde sabemos, no existe estudios previos sobre la correlación entre los niveles basales de citoquinas/quimioquinas en la lágrima y el humor acuoso antes de la cirugía y la aparición de EMCP...
Cataracts remain one of the leading causes of blindness worldwide. Cataract surgery is the curative treatment of choice. Pseudophaquic cystoid macular edema (PCME) is the most common cause of vision loss after cataract surgery and manifests as an accumulation of fluid in the macular area 4 to 6 weeks after surgery. PCME is a self-limited complication whose physiopathology remains partially unknown. Currently, bead-based multiplex assay enables the simultaneous analysis of several cytokines/chemokines and the use of this technology could contribute to a better understanding of the role of such molecules in the physiopathology of several diseases. As far as we know there are no previous studies on the correlation between basal levels on cytokines/chemokines in tears and aqueous humor before cataract surgery and the development of PCME...
Cataracts remain one of the leading causes of blindness worldwide. Cataract surgery is the curative treatment of choice. Pseudophaquic cystoid macular edema (PCME) is the most common cause of vision loss after cataract surgery and manifests as an accumulation of fluid in the macular area 4 to 6 weeks after surgery. PCME is a self-limited complication whose physiopathology remains partially unknown. Currently, bead-based multiplex assay enables the simultaneous analysis of several cytokines/chemokines and the use of this technology could contribute to a better understanding of the role of such molecules in the physiopathology of several diseases. As far as we know there are no previous studies on the correlation between basal levels on cytokines/chemokines in tears and aqueous humor before cataract surgery and the development of PCME...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 30-06-2022