Publication: Estudio de la coroides de la población sana mediante tomografía de coherencia óptica swept-source
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2018-01-08
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Universidad Complutense de Madrid
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Abstract
Empleando la tomografía de coherencia óptica Swept-Source (SS-OCT): - Evaluar el grosor coroideo (GC) en la población infantil. - Determinar el perfil del GC en población sana. - Analizar las características morfológicas de la interfase coroides-esclerótica. - Determinar la diferencia interocular en el perfil del GC macular. - Estudiar el GC y sus variaciones con la edad, así como la morfología y cambios de las tres capas anatómicas de la coroides. - Analizar la densidad de la coroides de la población sana. Material y Métodos: Los criterios de inclusión fueron: mejor agudeza visual corregida entre 20/20 y 20/25, equivalente esférico (EE) entre ±3 dioptrías (D) y ausencia de enfermedades sistémicas u oculares. Las medidas y determinaciones fueron realizadas por dos o tres investigadores independientes y enmascarados según el caso, con un prototipo SS-OCT (Topcon Co., Japón). Para el estudio de la población infantil se realizó un estudio comparativo transversal no intervencionista del área macular de 83 ojos de 43 pacientes pediátricos (<18 años). El GC macular se determinó independientemente por 3 observadores manualmente a intervalos de 750 μm midiendo la distancia desde el borde posterior del epitelio pigmentario de la retina (EPR) hasta la unión coroidesesclerótica, a lo largo de una línea de 4500 μm centrada en la fóvea. El GC pediátrico se comparó con el de 75 ojos de 50 voluntarios adultos sanos (≥18 años)...
While using Swept-Source optical coherence tomography (SS-OCT): - Study choroidal thickness of healthy pediatric population. - Study the choroidal thickness profile of healthy population. - Study the morphologic characteristics of the choroid-sclera interface. - Study interocular differences regarding the macular choroidal thickness profile. - Study choroidal thickness, its variations with age and the changes that appear within its three layers. - To analyse the vascular density of the choroid in a healthy population. Material y Methods: Inclusion criteria were: Best corrected visual acuity between 20/20 and 20/25, spherical equivalent (SE) between ±3 diopters (D) and absence of systemic or ocular diseases. Measures were performed by 2 or 3 independent, masked observers using a SS-OCT prototype (Topcon Co. Japan). A cross-sectional, non-interventional study of 276 eyes was performed to analyse the choroidal thickness profile and the morphology of the choroid-sclera interface. Two independent, masked observers studied these characteristics and classified the shape into concave (bowl-shaped) or inflection (S-shaped), manually measuring choroidal thickness from the posterior edge of the RPE and the choroidsclera junction under the fovea. They performed 8 more measures every 1000 μm towards temporal and nasal sectors. Analised subjects were stratified into 5 age groups...
While using Swept-Source optical coherence tomography (SS-OCT): - Study choroidal thickness of healthy pediatric population. - Study the choroidal thickness profile of healthy population. - Study the morphologic characteristics of the choroid-sclera interface. - Study interocular differences regarding the macular choroidal thickness profile. - Study choroidal thickness, its variations with age and the changes that appear within its three layers. - To analyse the vascular density of the choroid in a healthy population. Material y Methods: Inclusion criteria were: Best corrected visual acuity between 20/20 and 20/25, spherical equivalent (SE) between ±3 diopters (D) and absence of systemic or ocular diseases. Measures were performed by 2 or 3 independent, masked observers using a SS-OCT prototype (Topcon Co. Japan). A cross-sectional, non-interventional study of 276 eyes was performed to analyse the choroidal thickness profile and the morphology of the choroid-sclera interface. Two independent, masked observers studied these characteristics and classified the shape into concave (bowl-shaped) or inflection (S-shaped), manually measuring choroidal thickness from the posterior edge of the RPE and the choroidsclera junction under the fovea. They performed 8 more measures every 1000 μm towards temporal and nasal sectors. Analised subjects were stratified into 5 age groups...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Oftalmología y Otorrinolaringología, leída el 28-04-2017